Biodegradable Cancer Immunotherapy
Cancer immunotherapy is beckon of hope. It is using of immunity by activating our own immune system to reduce cancer.
This is the Yale University publication on bio-degradable Immuno-therapy method for cancer therapy.
In cancer cases, theÂ tumorsÂ are capable of suppressing the hostâs naturalÂ defensesÂ by producing agents that interrupt and ceases the production and operating process of immune system.
Hence, scientists from Yale University have developed a new mechanism which attacks theÂ tumorÂ areas stimulating the immune system of the body and simultaneously weakens the ability of theÂ tumorÂ in resisting to the immune system of our body.
A new biodegradable nano-particle is developed by the Yale team members, which liberates a combination of two different therapeutic agents toÂ tumorÂ sites, slowly releasing the agents into theÂ tumorÂ vessels.
The two different therapeutic agents present in the biodegradable nano-particle are:-
- Cytokine, a large soluble protein â It stimulates the bodyâs natural immune response.
- A small molecule drug inhibitor which is insoluble â This weakens the ability of theÂ tumorÂ in suppressing the immune system of our body.
Other drug combinations are also possible.
The double-loaded particle called aÂ nano-gelÂ is tested on live mice, by the researchers. TheÂ nano-gelÂ is administered both intravenously and directly into theÂ tumorsÂ in different experiments. More animal tests are planned in future.
AÂ bio-engineerÂ at Yale University and the projectâs principal investigator Tarek M. Fahmy says âWe believe this is a paradigm-changing immuno-therapeutic method for cancer therapy. In essence, itâs a one-two punch strategy that seems to work well for melanoma and may work even better with other cancers.â
Invention of a particle that enabled slow release of both the therapeutic agents with different characteristics was the main challenge faced by the researchers.
The researchers reported their results in the journal âNature Materialsâ. The components that they have used for this nano-particle were already approved by the U.S. Food and Drug Administration. This could speed up the future experiments on cancer immunotherapy with other ingredients and human trials.